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321 SNPs From Major IBD SNP Studies' Comparison

The Venn and UpSet Diagram show the shared SNPs between different major IBD SNP studies,321 unique IBD SNPs were identified after comparison.

IBD aoosiated SNPs

ID	RS_ID	Gene	Chr	SNP_index	Phenotype	OR_phenotype_loci	Pvalue_phenotype_loci
1	rs9726836	CCNL2	1	chr1:1388944:G:A	IBD	0.909918722	3.085E-13
2	rs1886730	TNFRSF14	1	chr1:2557169:T:C	UC	0.910646948	6.001E-16
3	rs225131	ERRFI1	1	chr1:8035426:T:C	IBD	0.896640749	1.032E-23
4	rs6426833	RNF186	1	chr1:19845367:G:A	UC	1.241971455	1.484E-74
5	rs34963268	ZBTB40	1	chr1:22384384:G:C	IBD	0.877656493	2.918E-25
6	rs7525903	RUNX3	1	chr1:24968082:G:A	CD	0.904566008	1.367E-13
7	rs140466198	PTAFR	1	chr1:28131939:C:T	CD	1.298097849	1.052E-08
8	rs12138864	PHC2	1	chr1:33337547:C:T	UC	1.066732246	3.983E-08
9	rs6687307	PLPP3	1	chr1:56454342:C:T	UC	0.918236772	4.516E-08
10	rs7543380	ATG4C	1	chr1:62768997:T:A	CD	0.928207474	8.587E-09
11	rs11581607	IL23R	1	chr1:67242007:G:A	IBD	0.547496067	3.79E-123
12	rs7552319	CHORDC1P5	1	chr1:70567336:A:C	UC	0.930158758	6.661E-09
13	rs17391694	GIPC2	1	chr1:78157942:C:T	CD	0.908009898	0.00004047
14	rs11165441	TGFBR3	1	chr1:91758790:G:A	IBD	0.934821198	4.452E-08
15	rs3767964	DR1	1	chr1:93349933:T:C	CD	1.087520136	2.186E-10
16	rs11583043	DPH5	1	chr1:101000498:C:T	IBD	1.035205544	0.001448
17	rs17572009	SLC25A24	1	chr1:108112400:A:C	IBD	1.065772619	6.486E-10
18	rs2476601	PTPN22	1	chr1:113834946:A:G	CD	1.218962394	5.575E-15
19	rs116062645	NOTCH2	1	chr1:119982857:G:T	IBD	1.227893378	2.628E-09
20	rs1336900	HORMAD1	1	chr1:150706557:G:A	IBD	0.926260284	4.11E-15
21	rs11204894	RORC	1	chr1:151820698:G:T	IBD	0.906830252	2.621E-17
22	rs3766920	SHC1	1	chr1:154962487:G:A	IBD	1.392220563	1.146E-13
23	rs34687326	SLAMF8	1	chr1:159830120:G:A	CD	0.876165744	3.816E-07
24	rs6658353	FCGR2A	1	chr1:161499264:G:C	UC	0.853081663	3.294E-39
25	rs6025	F5	1	chr1:169549811:C:T	IBD	0.850441205	0.000009384
26	rs10912488	AIMP1P2	1	chr1:172877652:A:G	CD	1.181872447	5.529E-24
27	rs72709461	ABL2	1	chr1:179134699:T:C	CD	1.125019085	2.139E-10
28	rs10798069	PLA2G4A	1	chr1:186906327:G:T	CD	0.944027483	0.0000068
29	rs10801047	-	1	chr1:191590226:A:T	IBD	0.981768247	0.2773
30	rs2224873	DENND1B	1	chr1:197676319:T:A	IBD	1.09921908	1.416E-15
31	rs74359027	PTPRC	1	chr1:198689168:TA:T	IBD	0.904385112	1.296E-12
32	rs2816980	NR5A2	1	chr1:200108907:G:T	UC	1.159165095	3.251E-12
33	rs35730213	INAVA	1	chr1:200905101:G:C	IBD	0.864503435	5.836E-34
34	rs11240504	CDK18	1	chr1:205516162:T:A	UC	1.07669913	2.374E-08
35	rs3024495	IL10	1	chr1:206769068:C:T	IBD	1.229613632	5.168E-55
36	rs2073486	IRF6	1	chr1:209802870:G:A	IBD	1.055484602	1.664E-08
37	rs11582528	PSEN2	1	chr1:226819948:C:T	UC	0.917685995	1.546E-08
38	rs10910476	IRF2BP2	1	chr1:234599210:C:T	IBD	1.066199013	7.057E-11
39	rs11894081	LINC01248	2	chr2:5523876:G:T	IBD	0.997303642	0.7914
40	rs7578575	DNMT3A	2	chr2:25265950:T:A	IBD	1.084370897	1.543E-15
41	rs1260326	GCKR	2	chr2:27508073:T:C	CD	0.902668412	2.283E-16
42	rs12478126	FOSL2	2	chr2:28423081:C:T	CD	1.110821687	2.962E-16
43	rs78487399	THADA	2	chr2:43582208:G:C	CD	1.199134444	4.178E-13
44	rs67927699	PUS10	2	chr2:60960280:G:C	IBD	1.14042386	4.075E-37
45	rs6759003	RN7SL51P	2	chr2:62332070:T:C	CD	0.927836265	4.756E-09
46	rs1370394	SPRED2	2	chr2:65453176:T:G	IBD	1.065666047	8.554E-11
47	rs1882348	IL18R1	2	chr2:102368211:T:A	IBD	0.905652138	1.595E-26
48	rs12475901	NCK2	2	chr2:105777237:G:A	CD	0.971999489	0.07981
49	rs72837826	BCL2L11	2	chr2:111175424:G:T	UC	1.126144667	1.467E-08
50	rs55678466	BIN1	2	chr2:127092119:T:C	IBD	1.054429645	2.486E-08
51	rs56862595	TEX41	2	chr2:144784617:T:C	IBD	0.893507992	1.821E-09
52	rs4664304	PLA2R1	2	chr2:159937497:A:G	IBD	0.978925243	0.02197
53	rs2111485	FAP	2	chr2:162254026:A:G	IBD	0.937348626	3.386E-11
54	rs151175749	PDK1	2	chr2:172559679:C:G	CD	1.124794104	9.575E-07
55	rs2124440	ITGA4	2	chr2:181463487:G:A	IBD	0.921271959	3.98E-17
56	rs2595392	ITGAV	2	chr2:186665389:C:G	IBD	0.90104507	6.228E-09
57	rs142152795	NAB1	2	chr2:190704810:C:T	CD	1.428607223	2.107E-09
58	rs6738825	PLCL1	2	chr2:198032171:A:G	CD	0.913657047	3.212E-11
59	rs34119476	AC019330.1	2	chr2:198719455:A:G	UC	1.109933385	1.898E-19
60	rs3769684	CD28	2	chr2:203720036:T:C	IBD	0.902668412	1.552E-12
61	rs11690316	CXCR1	2	chr2:218152739:A:G	IBD	1.083395402	4.56E-18
62	rs4973341	CCL20	2	chr2:227795646:C:T	IBD	1.079394246	1.802E-13
63	rs13385151	SP140	2	chr2:230251261:C:T	CD	1.166724208	2.195E-16
64	rs12692254	ATG16L1	2	chr2:233252565:A:T	CD	1.243587068	2.191E-63
65	rs34236350	GPR35	2	chr2:240628909:C:T	IBD	1.183646586	7.706E-54
66	rs115622046	BOK	2	chr2:241546197:C:T	IBD	0.920351147	5.932E-08
67	rs35320439	GAL3ST2	2	chr2:241797926:T:C	IBD	1.030351494	0.007419
68	rs73180609	SATB1-AS1	3	chr3:18770480:A:C	CD	1.118848465	9.125E-11
69	rs6770038	TGFBR2	3	chr3:30608835:T:C	IBD	1.073688589	4.36E-08
70	rs113010081	CCRL2	3	chr3:46415921:T:C	UC	1.143164164	2.466E-11
71	rs1131095	APEH	3	chr3:49676792:T:C	IBD	1.177389854	1.932E-55
72	rs138317798	RPL29	3	chr3:52013158:TGGA:T	UC	1.144880197	1.429E-08
73	rs35783750	RFT1	3	chr3:53100847:T:C	CD	0.908009898	1.215E-13
74	rs2593855	FOXP1	3	chr3:71126344:C:T	IBD	0.929879752	6.683E-10
75	rs503734	IMPG2	3	chr3:101304904:A:G	CD	0.938380277	8.339E-07
76	rs616597	NFKBIZ	3	chr3:101850882:A:C	IBD	1.059291194	2.534E-08
77	rs1317244	CD200	3	chr3:112334718:G:A	CD	1.091223998	0.0001383
78	rs6763931	ZBTB38	3	chr3:141383991:G:A	CD	1.117618408	4.423E-19
79	rs56116661	LPP	3	chr3:188683372:C:T	IBD	0.903210176	3.725E-15
80	rs16844401	HGFAC	4	chr4:3447925:G:A	IBD	1.134282168	1.117E-12
81	rs4692386	LINC02357	4	chr4:26130739:T:C	IBD	1.026648897	0.008608
82	rs61797472	ARAP2	4	chr4:36061370:A:G	IBD	1.065026839	6.313E-11
83	rs73243351	LINC02513	4	chr4:38333446:G:A	IBD	1.158238133	2.856E-22
84	rs11734570	KLF3	4	chr4:38586832:G:A	CD	1.054956992	0.00003854
85	rs7438704	SLAIN2	4	chr4:48361228:A:G	IBD	1.013794275	0.1408
86	rs2472649	CXCL5	4	chr4:73991991:A:G	UC	1.065346395	0.00007314
87	rs13107325	SLC39A8	4	chr4:102267552:C:T	CD	1.222502515	7.18E-13
88	rs2903386	TET2	4	chr4:105178652:T:C	IBD	0.932114144	8.193E-14
89	rs147909357	IL2	4	chr4:122523884:G:GT	IBD	1.086215895	6.177E-19
90	rs4081846	CEP72	5	chr5:573904:G:A	UC	0.895117755	2.438E-08
91	rs3776414	DAP	5	chr5:10689450:T:G	IBD	1.074977789	5.673E-14
92	rs3194051	IL7R	5	chr5:35876172:A:G	IBD	1.03790058	0.0007485
93	rs395157	OSMR	5	chr5:38867630:C:T	IBD	1.08047418	9.881E-17
94	rs7725052	TTC33	5	chr5:40487168:C:T	IBD	1.134282168	1.399E-40
95	rs10065637	ANKRD55	5	chr5:56143024:C:T	CD	0.910738017	0.000001055
96	rs4703855	PTCD2	5	chr5:72398072:C:T	CD	0.944216307	0.0000123
97	rs6870798	TMEM174	5	chr5:73248171:C:T	CD	0.917685995	1.122E-09
98	rs10041920	SERINC5	5	chr5:80229545:A:G	IBD	0.948474855	2.458E-08

99	rs6873866	ERAP2	5	chr5:96912106:T:C	CD	0.894491391	3.134E-16
100	rs7705924	LINC00492	5	chr5:102611094:A:G	IBD	1.047179124	0.07348
101	rs341295	EPB41L4A	5	chr5:112513193:C:T	IBD	1.051691689	4.933E-08
102	rs2188962	SLC22A5	5	chr5:132435113:C:T	IBD	1.133601803	2.854E-32
103	rs254560	PITX1	5	chr5:135107916:G:A	UC	1.091660575	1.73E-13
104	rs181826	NDFIP1	5	chr5:142146492:C:A	IBD	1.074118151	4.652E-14
105	rs59672579	ARHGAP26	5	chr5:142866576:C:T	IBD	0.90728378	1.483E-10
106	rs1000113	IRGM	5	chr5:150860514:C:T	IBD	1.168943092	1.437E-32
107	rs1363232	TIMD4	5	chr5:156956411:A:G	IBD	0.94317824	2.271E-08
108	rs755374	IL12B	5	chr5:159402286:C:T	IBD	1.182936611	5.212E-67
109	rs2101594	STK10	5	chr5:172151212:C:T	IBD	1.053586439	4.867E-08
110	rs564349	ERGIC1	5	chr5:172897975:G:A	IBD	0.929043237	2.979E-13
111	rs359457	CPEB4	5	chr5:173852839:C:T	CD	1.052007244	0.00004336
112	rs10051765	RGS14	5	chr5:177372991:T:C	IBD	1.078207565	1.238E-14
113	rs55982276	PHYKPL	5	chr5:178217126:CAG:C	UC	0.865628021	8.757E-09
114	rs77688705	DUSP22	6	chr6:246629:G:A	IBD	0.86458989	4.708E-09
115	rs17309827	SLC22A23	6	chr6:3433084:T:G	CD	0.94317824	0.000003623
116	rs17119	RNU6-793P	6	chr6:14719265:G:A	IBD	1.098340056	5.009E-13
117	rs181635615	ID4	6	chr6:19787512:G:A	UC	0.736165737	9.414E-09
118	rs2328546	CDKAL1	6	chr6:20657114:T:C	IBD	1.106387275	4.861E-19
119	rs4710973	AL031767.2	6	chr6:21385471:T:C	IBD	0.923300988	7.852E-16
120	rs9271511	HLA-DQA1	6	chr6:32621706:G:A	UC	0.707300265	1.38E-158
121	rs67289879	TAF8	6	chr6:42039665:C:T	CD	1.103845508	3.299E-07
122	rs1044690	TMEM151B	6	chr6:44277504:G:C	CD	0.916860449	4.306E-08
123	rs943689	BACH2	6	chr6:90274316:C:T	CD	0.906648904	1.567E-09
124	rs9480634	ATG5	6	chr6:106020611:C:T	IBD	0.922285915	4.246E-17
125	rs73534586	TRAF3IP2	6	chr6:111594960:G:A	UC	1.214339126	1.263E-13
126	rs2858829	DSE	6	chr6:116447754:A:G	UC	1.068440384	9.116E-09
127	rs210648	DCBLD1	6	chr6:117522909:A:G	IBD	1.059714996	2.823E-09
128	rs9482770	RSPO3	6	chr6:127121947:T:C	CD	1.085564361	6.193E-11
129	rs9491891	PTPRK	6	chr6:127956006:A:G	CD	1.096803456	0.000007333
130	rs6933404	LINC02539	6	chr6:137638098:T:C	UC	1.148090354	7.593E-19
131	rs12191421	PHACTR2	6	chr6:143570283:A:G	IBD	0.891990319	2.862E-09
132	rs7758080	TAB2	6	chr6:149255943:A:G	CD	1.08534727	7.647E-10
133	rs212408	TAGAP	6	chr6:159049210:G:T	CD	0.902758683	1.33E-12
134	rs6939196	RNASET2	6	chr6:166965500:C:T	IBD	0.901225297	3.4E-24
135	rs74572369	ADAP1	7	chr7:944282:T:A	CD	0.79485148	6.695E-14
136	rs2260230	GNA12	7	chr7:2783352:T:A	UC	0.89906495	9.807E-17
137	rs748670681	TNRC18	7	chr7:5397122:C:T	IBD	2.276183188	8.99E-93
138	rs2034400	LINC02889	7	chr7:17559004:T:G	UC	1.077776368	5.824E-09
139	rs76380568	ABCB5	7	chr7:20542073:T:C	IBD	0.876603937	1.139E-10
140	rs10486483	SKAP2	7	chr7:26852821:G:A	CD	1.081230776	0.000000525
141	rs11495981	JAZF1	7	chr7:28137682:C:T	CD	1.096803456	7.074E-10
142	rs73120731	ELMO1	7	chr7:37417880:A:G	CD	1.143507165	5.286E-13
143	rs1990134	GLI3	7	chr7:41935319:C:T	UC	1.080366138	1.129E-09
144	rs6976037	EPS15P1	7	chr7:46834111:A:T	UC	1.071757688	5.224E-09
145	rs4917129	IKZF1	7	chr7:50283578:T:C	IBD	1.086650468	6.351E-19
146	rs117026326	GTF2I	7	chr7:74711703:C:T	IBD	1.202616981	1.818E-11
147	rs144341967	SMURF1	7	chr7:99150512:T:G	IBD	1.154191386	6.787E-09
148	rs1734907	EPO	7	chr7:100717894:A:G	CD	0.910555888	5.129E-07
149	rs4380874	SLC26A3	7	chr7:107839870:T:C	UC	0.872057428	1.643E-28
150	rs38902	ST7	7	chr7:117249664:G:A	UC	0.939507009	1.777E-07
151	rs3757387	IRF5	7	chr7:128936032:T:C	UC	1.109378557	1.503E-17
152	rs243500	CUL1	7	chr7:148742273:G:C	IBD	0.936318109	2.802E-11
153	rs17057051	PTK2B	8	chr8:27370037:A:G	CD	0.938849584	0.000005247
154	rs77535993	IDI1P2	8	chr8:48207903:G:T	UC	0.901135179	5.497E-09
155	rs12677663	SBSPON	8	chr8:73095112:G:T	IBD	1.026751567	0.007324
156	rs389848	RIPK2	8	chr8:89784739:T:G	CD	0.963001798	0.08451
157	rs2721933	TRPS1	8	chr8:115614948:T:C	UC	1.072722704	2.002E-08
158	rs4380956	TRIB1	8	chr8:125516832:G:A	IBD	1.077560834	3.229E-15
159	rs938649	LINC00824	8	chr8:128540288:G:T	CD	0.841726617	1.553E-14
160	rs1991866	CCDC26	8	chr8:129611859:G:C	IBD	0.948854321	2.231E-08
161	rs438041	DENND3	8	chr8:141164479:C:T	IBD	1.023061907	0.01809
162	rs79832570	SPATC1	8	chr8:144042819:T:C	CD	1.225317507	5.708E-11
163	rs682251	DOCK8	9	chr9:271455:T:C	CD	0.923393323	1.557E-08
164	rs36051895	JAK2	9	chr9:4981866:G:T	IBD	1.145567331	1.698E-43
165	rs9408254	FAM205A	9	chr9:34736161:A:G	CD	1.091442264	0.00003379
166	rs11142085	SPATA31C2	9	chr9:88081422:G:A	IBD	1.0616242	0.02628
167	rs4743820	AUH	9	chr9:91166134:C:T	UC	1.068013093	7.95E-08
168	rs10992396	IPPK	9	chr9:92674850:A:G	IBD	1.086324522	1.384E-12
169	rs56211063	TNFSF15	9	chr9:114823617:G:C	IBD	1.387911362	3.04E-89
170	rs4986790	TLR4	9	chr9:117713024:A:G	CD	1.142021571	0.000006454

图文展示

RS_ID

Gene

Chr

SNP_index

Phenotype

OR_phenotype_loci

Pvalue_phenotype_loci

171	rs8176719	ABO	9	chr9:133257521:T:TC	CD	1.084154044	1.298E-09
172	rs3812565	SNAPC4	9	chr9:136378050:T:C	IBD	1.130658267	3.222E-37
173	rs12722489	IL2RA	10	chr10:6060049:C:T	IBD	0.916218872	2.428E-11
174	rs4748198	PRKCQ	10	chr10:6607973:C:T	IBD	0.924409614	6.844E-12
175	rs7911117	ABI1	10	chr10:26890667:T:G	IBD	0.960501246	0.003316
176	rs7898978	MAP3K8	10	chr10:30410871:T:C	IBD	0.924594515	1.481E-15
177	rs12764283	CREM	10	chr10:35241532:G:A	IBD	1.101529865	7.711E-24
178	rs769009	FRMPD2	10	chr10:48182406:G:T	CD	0.923208663	7.339E-09
179	rs2790211	IPMK	10	chr10:58243611:T:C	IBD	0.920627294	4.702E-14
180	rs10761659	ALDH7A1P4	10	chr10:62685804:A:G	IBD	1.152922473	3.896E-51
181	rs2688607	PLAU	10	chr10:73903978:A:G	CD	1.122659024	5.962E-17
182	rs1250566	ZMIZ1	10	chr10:79286696:G:A	IBD	0.898435825	1.274E-28
183	rs1870148	TSPAN14	10	chr10:80511585:G:A	CD	1.137121421	8.519E-12
184	rs11203002	CH25H	10	chr10:89146767:C:G	UC	0.891366144	2.985E-12
185	rs7918084	KIF11	10	chr10:92669710:C:T	IBD	1.071972061	2.015E-12
186	rs11188950	LCOR	10	chr10:96860106:T:G	UC	1.174097773	3.425E-11
187	rs4409764	NKX2-3	10	chr10:99524480:T:G	IBD	0.85018611	3.442E-72
188	rs113369211	BTRC	10	chr10:101436625:AATAGATAGATAGATAG:AATAGATAGATAGATAGATAG	UC	0.816441513	1.803E-08
189	rs11591780	MFSD13A	10	chr10:102465559:C:G	UC	1.070900625	5.073E-09
190	rs10884966	DUSP5	10	chr10:110425838:G:A	CD	1.147516452	4.65E-22
191	rs111456533	FAM53B	10	chr10:124750812:G:A	CD	0.919707127	0.000002249
192	rs10734105	TCERG1L	10	chr10:131373856:G:A	IBD	1.009040622	0.3891
193	rs907613	TNNI2	11	chr11:1853062:G:A	IBD	1.07669913	4.547E-13
194	rs9645621	NUCB2	11	chr11:17311651:A:G	IBD	1.063536845	4.204E-08
195	rs77531520	PRR5L	11	chr11:36410895:C:T	IBD	1.142021571	1.444E-08
196	rs181068528	OR5AR1	11	chr11:56679337:A:T	IBD	1.80092424	7.592E-11
197	rs11229030	SLC43A3	11	chr11:57435536:C:T	IBD	0.998401279	0.8671
198	rs10896794	LPXN	11	chr11:58571651:T:C	UC	0.914296831	2.388E-08
199	rs11230563	CD6	11	chr11:61008737:C:T	IBD	0.93379346	3.114E-11
200	rs174564	FADS1	11	chr11:61820833:A:G	IBD	1.078854683	8.356E-16
201	rs1783521	CCDC88B	11	chr11:64338819:T:C	CD	0.909282002	1.146E-10
202	rs2303385	EFEMP2	11	chr11:65873091:G:A	CD	0.927094293	3.347E-08
203	rs11235667	FCHSD2	11	chr11:73152652:A:G	CD	1.221402758	0.000001277
204	rs71040008	EMSY	11	chr11:76587581:G:GT	IBD	1.156849081	1.397E-44
205	rs6592362	TMEM135	11	chr11:87414396:A:G	IBD	0.987676563	0.2357
206	rs79608745	LINC02748	11	chr11:91270280:A:G	IBD	1.012882271	0.5916
207	rs483905	MAML2	11	chr11:96290263:G:A	UC	1.055484602	0.00001633
208	rs561722	NXPE1	11	chr11:114516108:C:T	UC	0.911922747	9.262E-15
209	rs141340254	MPZL2	11	chr11:118273990:A:G	CD	0.621077131	4.658E-08
210	rs3176905	CXCR5	11	chr11:118884921:T:C	IBD	0.955137471	0.0008656
211	rs11221332	ETS1	11	chr11:128511079:C:T	IBD	1.064388015	1.661E-07
212	rs4020660	LTBR	12	chr12:6402491:G:A	CD	1.0957072	4.095E-11
213	rs11612508	DUSP16	12	chr12:12504579:A:G	UC	1.052533379	0.0001059
214	rs181198871	-	12	chr12:37910758:G:A	IBD	1.644604615	0.000006364
215	rs75913487	RNU6-713P	12	chr12:40562563:T:C	CD	1.635420569	6.067E-20
216	rs11168249	HDAC7	12	chr12:47814585:T:C	UC	1.071757688	6.256E-08
217	rs199762200	ERBB3	12	chr12:56076060:G:A	IBD	0.883910028	7.181E-09
218	rs1558746	IFNG	12	chr12:68111348:G:A	IBD	1.144536784	1.342E-26
219	rs61576454	LYZ	12	chr12:69348988:AT:A	IBD	0.923024039	4.304E-08
220	rs4762271	ELK3	12	chr12:96137691:A:G	CD	1.100869145	6.282E-11
221	rs117121174	ATP2A2	12	chr12:110259525:G:A	CD	0.744010598	1.346E-10
222	rs11066188	HECTD4	12	chr12:112172910:G:A	IBD	1.080582232	7.248E-13
223	rs113281820	MIR4472-2	12	chr12:116408331:C:T	IBD	1.043520403	0.0005682
224	rs11064881	CIT	12	chr12:119709120:G:A	IBD	1.116501348	7.322E-09
225	rs17085007	RPS21P8	13	chr13:26957130:T:C	UC	1.191365347	3.793E-35
226	rs17630801	ELF1	13	chr13:40965681:A:C	IBD	1.210701568	2.355E-20
227	rs9525562	DGKH	13	chr13:42037531:C:A	CD	0.913657047	1.389E-11
228	rs1535903	FAM216B	13	chr13:42797254:C:T	UC	0.925612128	1.042E-08
229	rs1373904	LACC1	13	chr13:43901262:A:G	CD	1.175507536	3.631E-30
230	rs2026029	FNDC3A	13	chr13:49021195:A:G	IBD	1.054429645	3.976E-08
231	rs184429843	NEK5	13	chr13:52062509:C:T	IBD	1.708814747	4.069E-09
232	rs9585037	UBAC2	13	chr13:99348586:A:T	IBD	0.915303111	4.92E-12
233	rs743228	NFKBIA	14	chr14:35390868:C:T	CD	0.912287589	3.51E-12
234	rs4902367	MAX	14	chr14:65142694:C:G	UC	1.079394246	2.786E-09
235	rs194746	ZFP36L1	14	chr14:68816170:C:T	IBD	1.08047418	3.462E-17
236	rs1569328	FOS	14	chr14:75275048:C:T	IBD	0.915120068	3.092E-13
237	rs4462528	GALC	14	chr14:87959953:T:C	IBD	1.156849081	5.484E-24
238	rs11627111	ELK2AP	14	chr14:105686797:A:G	IBD	0.870228028	4.29E-08
239	rs147034755	RASGRP1	15	chr15:38617263:A:C	CD	1.109267625	2.631E-09
240	rs28374715	CHP1	15	chr15:41271752:A:G	UC	0.936786385	0.00001154
241	rs11071559	RORA	15	chr15:60777789:C:T	IBD	0.921548382	1.196E-09
242	rs56375023	SMAD3	15	chr15:67156025:G:A	IBD	1.123894628	1.518E-23
243	rs1864239	ST20	15	chr15:79913012:A:G	IBD	0.979708696	0.3611
244	rs12440543	ABHD17C	15	chr15:80675204:T:C	IBD	0.938943474	1.476E-09
245	rs71407313	CRTC3	15	chr15:90600362:C:T	IBD	0.888962701	1.992E-13
246	rs7170683	LRRK1	15	chr15:100948377:T:C	CD	1.073795964	4.795E-08
247	rs191241541	PKD1	16	chr16:2117121:C:T	IBD	1.85132204	2.797E-09
248	rs11641184	LITAF	16	chr16:11610795:C:A	IBD	1.085021714	2.14E-18
249	rs59790099	PRKCB	16	chr16:23857964:G:A	UC	0.91101128	2.09E-11
250	rs201121732	IL21R	16	chr16:27384341:C:CT	UC	1.252322716	2.532E-08
251	rs4787458	IL27	16	chr16:28519966:A:G	IBD	1.091551414	1.962E-18
252	rs77948921	CD2BP2	16	chr16:30328432:G:A	UC	1.09089668	9.435E-12
253	rs5743289	NOD2	16	chr16:50722863:C:T	CD	1.524093794	7.56E-113
254	rs6499186	CDH3	16	chr16:68626662:C:T	UC	1.092425005	3.36E-09
255	rs8055490	TMEM170A	16	chr16:75463237:C:T	IBD	0.94980365	2.754E-08
256	rs9938250	WWOX	16	chr16:78768798:A:G	IBD	0.931461892	2.71E-08
257	rs187975120	CDYL2	16	chr16:80804680:G:T	IBD	1.264529353	3.5E-09
258	rs11548656	PLCG2	16	chr16:81883307:A:G	IBD	0.823410844	1.183E-11
259	rs76640285	CDH13	16	chr16:82844608:GA:G	CD	1.098669607	4.477E-08
260	rs16940202	IRF8	16	chr16:85980635:T:C	IBD	1.132015871	1.239E-25
261	rs16946807	CRK	17	chr17:1453285:C:A	CD	1.074010744	2.451E-08
262	rs415704	CLEC10A	17	chr17:7074375:C:T	IBD	0.943083927	3.66E-08
263	rs2948542	KSR1	17	chr17:27529460:A:G	CD	1.104176712	1.631E-14
264	rs4795894	CCL7	17	chr17:34264425:C:T	IBD	0.915211585	8.333E-19
265	rs11658993	IKZF3	17	chr17:39784555:C:T	IBD	1.132695284	1.116E-41
266	rs9911533	SMARCE1	17	chr17:40619224:C:T	UC	1.096584117	1.944E-14
267	rs12601611	STAT3	17	chr17:42345810:C:T	IBD	0.875290017	8.995E-40
268	rs4598971	ITGB3	17	chr17:47259971:T:G	CD	0.986294783	0.3134
269	rs1470831	SKAP1	17	chr17:48268286:C:T	IBD	0.929321992	3.478E-10
270	rs3853824	C17orf67	17	chr17:56803632:T:C	CD	1.05992696	0.00002073

271	rs1292053	TUBD1	17	chr17:59886176:A:G	IBD	1.067372478	7.43E-13
272	rs9904398	METTL2A	17	chr17:62449865:G:A	IBD	0.961654539	0.07062
273	rs8072795	SLC39A11	17	chr17:72643045:G:A	IBD	0.896551089	2.737E-13
274	rs17736589	CYTH1	17	chr17:78741036:A:G	UC	1.070044247	0.00001419
275	rs116885423	PVALEF	17	chr17:81183249:G:T	UC	1.569096538	1.88E-08
276	rs663411	SMCHD1	18	chr18:2734945:C:G	IBD	1.057069017	1.78E-08
277	rs547268	PTPN2	18	chr18:12823057:G:T	IBD	0.890119104	1.907E-25
278	rs16978179	SETBP1	18	chr18:44806588:T:C	CD	1.181754265	1.248E-13
279	rs138863186	CTIF	18	chr18:48863700:C:CTTG	IBD	0.817013223	6.111E-09
280	rs9635956	ELAC1	18	chr18:50977537:G:A	IBD	1.057386185	1.609E-08
281	rs9319943	GRP	18	chr18:59212595:T:C	CD	1.073151879	0.000004512
282	rs727088	CD226	18	chr18:69863203:G:A	IBD	0.963001798	0.00004358
283	rs7236492	NFATC1	18	chr18:79460616:C:T	IBD	0.947242639	0.0001207
284	rs11669443	SBNO2	19	chr19:1109216:G:A	IBD	1.10871313	9.956E-21
285	rs2240751	MFSD12	19	chr19:3548233:A:G	CD	1.143278486	5.957E-08
286	rs12720356	TYK2	19	chr19:10359299:A:C	IBD	1.158585657	2.891E-16
287	rs172032	ELL	19	chr19:18522945:T:C	CD	1.08047418	7.33E-09
288	rs138636798	SLC7A10	19	chr19:33260220:T:TC	IBD	1.143278486	5.514E-24
289	rs587259	LSM14A	19	chr19:34165501:C:T	IBD	0.98452105	0.1492
290	rs1644682	ZNF568	19	chr19:36991870:G:A	CD	0.927743486	5.578E-09
291	rs2604913	COQ8B	19	chr19:40712706:G:A	IBD	0.941482047	3.692E-10
292	rs55665939	PPP5C	19	chr19:46346189:A:G	CD	0.903933033	2.554E-09
293	rs646327	FUT2	19	chr19:48706594:A:G	CD	1.109045793	4.941E-12
294	rs34587409	RPS9	19	chr19:54203491:G:A	CD	1.091878929	7.128E-11
295	rs11672983	FCAR	19	chr19:54871595:G:A	UC	1.074870297	1.82E-09
296	rs4256018	FERMT1	20	chr20:6113242:T:G	IBD	1.061199636	1.856E-08
297	rs6042824	MACROD2	20	chr20:14618543:C:A	CD	0.914296831	1.095E-08
298	rs875519	NOL4L	20	chr20:32503432:T:C	IBD	1.068760964	2.368E-10
299	rs4911259	DNMT3B	20	chr20:32788476:T:G	IBD	1.038211997	0.0002266
300	rs6088765	MMP24	20	chr20:35211477:T:G	IBD	1.018468471	0.04851
301	rs6071961	AL009050.1	20	chr20:40169106:T:G	IBD	1.067692737	2.808E-08
302	rs17181845	ZHX3	20	chr20:41301389:T:G	IBD	1.076053304	1.949E-08
303	rs6017342	HNF4A	20	chr20:44436388:A:C	UC	1.202015823	5.295E-46
304	rs1883832	CD40	20	chr20:46118343:T:C	CD	0.904475555	1.274E-13
305	rs913678	LINC01271	20	chr20:50338887:T:C	IBD	0.940917327	3.897E-10
306	rs259964	ZNF831	20	chr20:59249254:A:G	IBD	0.932020937	1.011E-12
307	rs6062496	TNFRSF6B	20	chr20:63697746:G:A	IBD	1.150734	2.26E-44
308	rs7277261	CYCSP42	21	chr21:15448734:C:T	IBD	0.865628021	7.027E-40
309	rs2284553	IFNGR2	21	chr21:33404389:A:G	CD	1.115831649	1.844E-17
310	rs2836882	PSMG1	21	chr21:39094644:G:A	IBD	0.866927437	4.848E-40
311	rs13047030	TRAPPC10	21	chr21:44057275:A:G	IBD	0.924964427	9.169E-10
312	rs12158299	UBE2L3	22	chr22:21625295:C:T	IBD	1.117283173	2.995E-27
313	rs5761654	CRYBA4	22	chr22:26641724:G:C	IBD	0.948000736	3.549E-08
314	rs1003342	HORMAD2	22	chr22:30174033:A:G	IBD	0.928857447	1.591E-15
315	rs4821382	HMGXB4	22	chr22:35242122:G:C	UC	1.087302654	3.103E-10
316	rs2413430	CSF2RB	22	chr22:36908468:A:T	CD	0.820780141	9.728E-17
317	rs9611131	PDGFB	22	chr22:39266475:T:C	IBD	0.825389403	5.027E-38
318	rs727563	ACO2	22	chr22:41471373:C:T	IBD	0.978827355	0.03804
319	rs5771192	IL17REL	22	chr22:50003556:A:C	UC	1.106719241	1.118E-17
320	rs2427870	VGLL1	X	chrX:136581905:C:T	IBD	0.906830252	5.667E-13

Ref：Liu Z, Liu R, Gao H, Jung S, Gao X, Sun R, Liu X, Kim Y, Lee HS, Kawai Y, Nagasaki M, Umeno J, Tokunaga K, Kinouchi Y, Masamune A, Shi W, Shen C, Guo Z, Yuan K; FinnGen; International Inflammatory Bowel Disease Genetics Consortium; Chinese Inflammatory Bowel Disease Genetics Consortium; Zhu S, Li D, Liu J, Ge T, Cho J, Daly MJ, McGovern DPB, Ye BD, Song K, Kakuta Y, Li M, Huang H. Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries. Nat Genet. 2023 May;55(5):796-806. doi: 10.1038/s41588-023-01384-0. Epub 2023 May 8.

IBD associated SNPs

ID	Chr	Position (bp)	SNP	P value	PMID	Phenotype	Genes in locus
1	1	1247494	rs12103	8e-13	23128233	IBD	SCNN1D,CPSF3L,TAS1R3,RP4-758J18.2,MRPL20,UBE2J2,ACAP3,PUSL1,GLTPD1,DVL1,MXRA8,CCNL2,AURKAIP1
2	1	2501338	rs10797432	3e-12	23128233	UC	FAM213B,MMEL1,TNFRSF14
3	1	8022197	rs3766606	8.84e-18	26192919	IBD	VAMP3,UTS2,PARK7,ERRFI1,PER3,TNFRSF9,CAMTA1
4	1	20171860	rs6426833	8.56e-69	FM	UC,IBD	RNF186,OTUD3
5	1	22702231	rs12568930	1e-17	23128233	IBD	.
6	1	63049593	rs1748195	7.13e-08	26192919	CD	ANGPTL3,AL138847.1,DOCK7,USP1
7	1	67707690	rs11581607	8.76e-175	FM	IBD	INSL5,MIER1,IL12RB2,TCTEX1D1,WDR78,SLC35D1,C1orf141,IL23R,SERBP1,SGIP1
8	1	70995562	rs2651244	2e-08	23128233	IBD	.
9	1	78623626	rs17391694	2.62e-09	26192919	CD	FUBP1,DNAJB4,NEXN,GIPC2
10	1	92554283	rs34856868	9.8e-09	26192919	IBD	BRDT,EPHX4,BTBD8,KIAA1107,C1orf146,GLMN,GFI1,RPAP2,EVI5,TGFBR3
11	1	101466054	rs11583043	1.92e-06	26192919	IBD	AC093157.1,EXTL2,SLC30A7,DPH5
12	1	114165757	rs2636006	2.34e-42	FM	IBD	DCLRE1B,RSBN1,PTPN22,AP4B1,MAGI3,BCL2L15,PHTF1
13	1	120451190	rs3897478	2e-11	23128233	CD	ADAM30,NOTCH2
14	1	151801680	rs4845604	1.21e-17	26192919	IBD	RORC
15	1	155230131	rs3180018	2e-13	21102463	CD	SLC50A1,DPM3,KRTCAP2,MUC1,MTX1,SCAMP3,RUSC1,RXFP4,SSR2,EFNA1,RP11-201K10.3,TRIM46,THBS3,GBA,FAM189B,CLK2,HCN3,PKLR,FDPS,YY1AP1,DAP3,GON4L,RIT1,KIAA0907,UBQLN4,EFNA3,EFNA3,ASH1L,MSTO1,SYT11,ARHGEF2
16	1	159799910	rs34687326	1.06e-08	NOVEL	CD	SLAMF8
17	1	160856964	rs4656958	2.05e-11	26192919	IBD	ITLN1,ITLN2
18	1	161479745	rs1801274	2e-38	23128233	IBD	HSPA6,FCGR3A,FCGR3B,FCGR2B,FCGR2A
19	1	169519049	rs6025	2.51e-08	26192919	IBD	CCDC181,SLC19A2,F5,SELP,SELL,SELE,ATP1B1,NME7,BLZF1,C1orf112
20	1	172853460	rs7517810	4.53e-22	26192919	CD	.
21	1	186875459	rs10798069	2.49e-07	26192919	IBD	PLA2G4A
22	1	191559356	rs10801047	3e-08	17554261	CD	.
23	1	197701279	rs2488397	5.64e-18	FM	IBD	CRB1,DENND1B
24	1	198598663	rs7555082	2.54e-09	26192919	IBD	PTPRC
25	1	200101920	rs2816958	2e-17	23128233	IBD	NR5A2
26	1	200877562	rs7554511	3.2e-44	26192919	IBD	C1orf106,KIF21B,CACNA1S
27	1	206939904	rs3024505	2.99e-50	26192919	IBD	IL10
28	1	209970610	rs59043219	1.09e-08	NOVEL	IBD	DIEXF,IRF6
29	2	5664008	rs11894081	4e-09	23266558	CD	.
30	2	25097644	rs13407913	1.69e-20	26192919	IBD	POMC,ADCY3,DNAJC27,EFR3B,DNMT3A
31	2	27730940	rs1260326	1.74e-21	26192919	CD	SNX17,ZNF513,KRTCAP3,FNDC4,PPM1G,IFT172,GCKR,NRBP1
32	2	28614794	rs925255	3e-15	23128233	IBD	FOSL2
33	2	43806918	rs10495903	2e-14	21102463	IBD	ZFP36L2,THADA
34	2	61204856	rs7608910	2.6e-36	26192919	IBD	PUS10
35	2	62552321	rs11679753	2.65e-12	FM	CD	.
36	2	65667272	rs6740462	5.59e-12	26192919	IBD	SPRED2
37	2	102939036	rs13001325	2.51e-23	FM	IBD	IL1RL2,IL1RL1,IL18R1,IL18RAP,SLC9A4,IL1R2,IL1R1
38	2	145492382	rs11681525	4.08e-11	26192919	CD	.
39	2	160794008	rs4664304	2.61e-08	26192919	IBD	LY75-CD302,LY75,PLA2R1
40	2	163110536	rs2111485	4.6e-09	26192919	IBD	GCG,IFIH1,FAP,GCA,KCNH7
41	2	182308352	rs6740847	1.22e-13	NOVEL	IBD	ITGA4
42	2	187576378	rs144344067	1.29e-08	NOVEL	IBD	ITGAV,FAM171B
43	2	191931464	rs1517352	3.87e-14	26192919	IBD	STAT4
44	2	198896895	rs6738825	4e-09	21102463	UC	MARS2,HSPE1-MOB4,MOB4,BOLL,RFTN2,AC011997.1,PLCL1
45	2	199560757	rs17229679	7.05e-20	FM	UC	PLCL1,SATB2
46	2	204592021	rs3116494	5.11e-07	26192919	IBD	CD28
47	2	219151218	rs2382817	1.13e-13	26192919	IBD	CXCR2,CXCR1,GPBAR1,AAMP,RUFY4,ARPC2,PNKD,TMBIM1
48	2	228660112	rs111781203	2.16e-10	26192919	IBD	.
49	2	228670476	rs1811711	6.09e-09	NOVEL	UC	.
50	2	231097129	rs6716753	1.98e-17	26192919	CD	SP110,SP140
51	2	234161448	rs6752107	1.42e-73	FM	IBD	ATG16L1
52	2	241574401	rs4676408	2.59e-30	FM	IBD,UC	GPR35
53	2	242484701	rs76527535	2.87e-08	NOVEL	IBD	.
54	2	242737341	rs35320439	1.73e-05	26192919	IBD	GAL3ST2
55	3	18767404	rs4256159	9e-15	23128233	CD	.
56	3	46457412	rs113010081	4.21e-08	26192919	IBD	CCR1,CCRL2,CCR5,CCR3,CCR2
57	3	49721532	rs3197999	1.55e-52	26192919	IBD	TMA7,TREX1,UCN2,TMEM89,SLC26A6,WDR6,NDUFAF3,IMPDH2,KLHDC8B,RP11-3B7.1,C3orf62,GPX1,TCTA,AMT,APEH,PLXNB1,CCDC51,SHISA5,PFKFB4,UQCRC1,CELSR3,NCKIPSD,PRKAR2A,SLC25A20,ARIH2OS,P4HTM,DALRD3,QRICH1,QARS,LAMB2,CCDC71,C3orf84,USP4,NICN1,MST1,RNF123,ATRIP,COL7A1,I
58	3	53062661	rs9847710	1e-08	23128233	UC	RFT1,SFMBT1,RP11-894J14.5
59	3	53133149	rs2581828	6.46e-09	NOVEL	CD	RFT1,RP11-894J14.5
60	3	71175495	rs2593855	2.54e-09	NOVEL	IBD	FOXP1
61	3	101023748	rs503734	2.67e-08	NOVEL	IBD	IMPG2,SENP7
62	3	101569726	rs616597	9.34e-06	26192919	UC	NFKBIZ
63	3	141105570	rs724016	3.36e-06	26192919	CD	ZBTB38
64	3	188401160	rs56116661	5.67e-10	NOVEL	CD	LPP
65	4	3444503	rs2073505	1.46e-07	26192919	IBD	HGFAC
66	4	26132361	rs4692386	1.21e-08	26192919	IBD	.
67	4	38325036	rs6856616	4e-14	23850713	IBD	.
68	4	38588453	rs11734570	4.8e-08	NOVEL	IBD	.
69	4	48363245	rs7438704	3.42e-11	26192919	CD	SLAIN2
70	4	74857708	rs2472649	3e-08	23128233	IBD	PF4,PPBP,CXCL5
71	4	102865304	rs13126505	1.57e-14	26192919	CD,UC	NFKB1,SLC39A8,BANK1
72	4	106075498	rs2189234	1.95e-10	26192919	UC	TET2
73	4	123351431	rs1479918	1.07e-13	FM	IBD	IL2,IL21,KIAA1109,ADAD1
74	5	583442	rs4957048	1e-09	20228799	UC	AC026740.1,TPPP,SLC9A3,CEP72
75	5	10695526	rs2930047	9.78e-14	26192919	IBD	DAP
76	5	35876274	rs3194051	4e-08	21297633	UC	IL7R,CAPSL
77	5	38867732	rs395157	2.22e-20	26192919	IBD	OSMR
78	5	40410584	rs11742570	2e-82	23128233	IBD	.
79	5	55438851	rs10065637	4e-12	23128233	IBD	ANKRD55
80	5	71693899	rs4703855	7.16e-11	26192919	IBD	.
81	5	72539850	rs34804116	1.21e-12	FM	CD	.
82	5	96252803	rs1363907	4.87e-15	26192919	IBD	ERAP2,CTD-2260A17.2,LNPEP
83	5	101946798	rs7705924	2e-08	22412388	CD	SLCO4C1,SLCO6A1
84	5	130017287	rs4836519	4e-10	23128233	IBD	.
85	5	131770805	rs2188962	9.53e-53	FM	IBD	IL3,CSF2,HINT1,LYRM7,SLC22A4,C5orf56,IRF1,CDC42SE2,RAPGEF6,ACSL6,P4HA2,PDLIM4,SLC22A5,CTC-432M15.3,FNIP1
86	5	134443606	rs254560	8.55e-10	26192919	IBD	C5orf66
87	5	141513204	rs6863411	2.41e-14	26192919	IBD	NDFIP1
88	5	149605994	rs17656349	1.54e-08	NOVEL	UC	SLC6A7,CAMK2A
89	5	150277909	rs11741861	3e-37	23128233	IBD	RPS14,TCOF1,CD74,NDST1,SYNPO,MYOZ3,DCTN4,SMIM3,AC010441.1,IRGM,ZNF300,GPX3,ANXA6,SLC36A3,SLC36A2,RBM22,TNIP1,CCDC69,GM2A
90	5	158827769	rs56167332	7.17e-50	26192919	IBD	UBLCP1,IL12B
91	5	172324978	rs564349	1.54e-07	26192919	IBD	ERGIC1
92	5	173279842	rs359457	3e-12	21102463	IBD	CPEB4
93	5	176788570	rs4976646	3.23e-12	26192919	IBD	RGS14,SLC34A1
94	6	382559	rs7773324	5.84e-09	26192919	IBD	.
95	6	3433318	rs17309827	7e-09	21102463	IBD	SLC22A23
96	6	14719496	rs17119	2.18e-11	26192919	IBD	.
97	6	19781009	rs113986290	7.59e-09	NOVEL	UC	.
98	6	20812588	rs9358372	9e-14	23128233	CD	CDKAL1
99	6	21430730	rs71559680	1.78e-15	26192919	CD	.
100	6	32612397	rs6927022	5e-133	23128233	IBD	C6orf15,CDSN,PSORS1C2,HCG27,HLA-C,HLA-B,MCCD1,ATP6V1G2,LTA,TNF,LTB,NCR3,AIF1,BAG6,C6orf47,GPANK1,LY6G5B,LY6G5C,LY6G6F,MEGT1,LY6G6E,LY6G6D,DDAH2,SAPCD1,HSPA1L,HSPA1B,C6orf48,NEU1,ZBTB12,NELFE,DXO,AL645922.1,CYP21A2,FKBPL,PRRT1,EGFL8,RNF5,AGER,PBX2,HLA-DRA,
101	6	42007403	rs67289879	3.04e-08	NOVEL	IBD	CCND3
102	6	43795968	rs943072	2e-10	21297633	UC	.
103	6	90973159	rs1847472	2e-10	23128233	IBD	BACH2
104	6	106435269	rs7746082	1.29e-20	26192919	IBD	.
105	6	111848191	rs3851228	1.5e-15	26192919	IBD	KIAA1919,TRAF3IP2,SLC16A10,REV3L,FYN
106	6	116768917	rs2858829	8e-10	25082827	UC	FAM26F,TRAPPC3L
107	6	127456122	rs9491697	4e-10	23128233	CD	RSPO3
108	6	128277151	rs9491891	9.39e-17	FM	CD	THEMIS,PTPRK
109	6	138006504	rs6920220	1e-21	23128233	IBD	.
110	6	143898894	rs12199775	2e-08	23128233	IBD	PHACTR2
111	6	149577079	rs7758080	1.15e-07	26192919	IBD	TAB2
112	6	159490436	rs212388	1.8e-16	26192919	CD	.
113	6	167373547	rs1819333	7e-21	23128233	IBD	RP11-514O12.4,RNASET2,FGFR1OP,CCR6
114	7	2789880	rs798502	6e-17	23128233	IBD	AMZ1,GNA12
115	7	6545188	rs11768365	3.88e-08	NOVEL	IBD	FLJ20306,DAGLB,KDELR2,GRID2IP
116	7	17442679	rs1077773	5.96e-09	26192919	UC	.
117	7	20577298	rs149169037	3.26e-08	NOVEL	IBD	.
118	7	26892440	rs10486483	1.55e-11	26192919	CD,UC	HOXA1,HOXA2,HOXA4,HOXA6,HOXA9,HOXA11,HOXA13,HOXA3,HOXA5,HOXA7,RP1-170O19.20,HOXA10,SKAP2
119	7	28190730	rs56691573	2.22e-12	FM	CD	JAZF1
120	7	50304461	rs1456896	7e-15	23128233	IBD	C7orf72,ZPBP
121	7	98759117	rs9297145	8e-12	23128233	IBD	KPNA7,SMURF1
122	7	100315517	rs1734907	2e-13	23128233	IBD	GNB2,POP7,TFR2,ACTL6B,GIGYF1,EPO,SLC12A9,EPHB4
123	7	107480315	rs4380874	2e-26	23128233	UC	SLC26A3,DLD,LAMB1
124	7	116892846	rs38904	1e-08	23128233	UC	WNT2
125	7	128573967	rs4728142	1.92e-14	26192919	UC	IRF5
126	7	148220448	rs2538470	3e-11	26192919	IBD	.
127	7	148435339	rs243505	3.04e-10	NOVEL	IBD	CUL1,EZH2
128	8	27227554	rs17057051	5.5e-08	26192919	IBD	PTK2B
129	8	49129242	rs7011507	2.03e-08	26192919	IBD	.
130	8	74007347	rs12677663	2e-08	22412388	CD	SBSPON
131	8	90875918	rs7015630	1e-08	23128233	IBD	.
132	8	126534671	rs921720	8e-20	23128233	IBD	.
133	8	129567181	rs6651252	4e-18	21102463	IBD	.
134	8	130624105	rs1991866	2e-09	23128233	IBD	.
135	9	4981601	rs75900472	4.7e-48	26192919	IBD	.
136	9	34736158	rs9408254	1.95e-08	26974007	CD	CCL21,FAM205A
137	9	93928416	rs4743820	3.8e-09	26192919	IBD	AUH
138	9	117545666	rs6478106	5e-46	23266558	IBD	TNFSF15,TNFSF8
139	9	120475302	rs4986790	6.99e-09	26974007	CD	TLR4
140	9	139266405	rs10781499	4e-56	23128233	IBD	C9orf69,LHX3,DKFZP434A062,DNLZ,UBAC1,QSOX2,GPSM1,CARD9,SNAPC4,SDCCAG3,PMPCA,SEC16A,C9orf163,NOTCH1,NACC2,INPP5E
141	10	6094697	rs61839660	1.24e-14	FM	IBD	DKFZP667F0711,IL2RA,RBM17,PFKFB3,PRKCQ
142	10	27179596	rs7911117	1.84e-08	NOVEL	UC	.
143	10	30728101	rs1042058	6e-11	23128233	IBD	MAP3K8
144	10	35466185	rs34779708	2.39e-26	FM	IBD	CUL2,CREM,CCNY
145	10	59913151	rs1819658	9e-17	21102463	IBD	IPMK,CISD1
146	10	64445564	rs10761659	4.97e-53	26192919	IBD	ADO,ZNF365
147	10	75673101	rs2227564	7e-10	23128233	IBD	AC022400.2,FUT11,CHCHD1,PLAU,SEC24C,ZSWIM8,RP11-574K11.31,NDST2,C10orf55,CAMK2G
148	10	81060317	rs1250550	1e-30	21102463	IBD	ZMIZ1
149	10	82254047	rs6586030	9e-16	23128233	IBD	TSPAN14,SH2D4B
150	10	94436851	rs7911264	3e-08	23128233	IBD	HHEX,IDE,KIF11
151	10	101284237	rs4409764	1.16e-61	26192919	IBD	NKX2-3
152	10	104232716	rs3740415	1.03e-07	26192919	IBD	TMEM180,ACTR1A,SUFU
153	10	112186148	rs11195128	2e-10	23850713	CD	.
154	10	126439381	rs111456533	1.18e-09	NOVEL	IBD	METTL10,FAM175B,RP11-12J10.3,FAM53B
155	10	133172119	rs10734105	3e-08	22412388	CD	.
156	11	1874072	rs907611	1e-10	21297633	IBD	LSP1
157	11	57203009	rs11229030	8e-09	22412388	CD	RP11-872D17.8,SLC43A3
158	11	58408687	rs11229555	5.23e-12	26192919	IBD	OR5B2,OR5B12,OR5B21,AP001350.1,ZFP91,ZFP91-CNTF,CNTF,LPXN,GLYAT
159	11	60776209	rs11230563	1.71e-14	26192919	IBD	CD6
160	11	61564299	rs4246215	2e-15	23128233	IBD	FEN1,MYRF,TMEM258,FADS1,FADS2
161	11	64150370	rs559928	3.33e-13	26192919	IBD	TRPT1,DNAJC4,VEGFB,FKBP2,TEX40,TRMT112,PRDX5,FERMT3,NUDT22,PPP1R14B,PLCB3,BAD,GPR137,KCNK4,ESRRA,CCDC88B,RPS6KA4,STIP1
162	11	65656564	rs2231884	3e-10	23128233	CD	FIBP,CCDC85B,CFL1,SNX32,MUS81,EFEMP2,CTSW,FOSL1
163	11	72863697	rs11235667	7e-09	23850713	CD	.
164	11	76299649	rs11236797	2.25e-50	FM	IBD	.
165	11	87125438	rs6592362	2e-08	23128233	IBD	.
166	11	96023427	rs483905	3.16e-10	26192919	UC	MAML2
167	11	114397162	rs200349593	3.56e-20	FM	UC	RBM7,REXO2,NXPE4,NXPE1,RP11-212D19.4
168	11	118754353	rs630923	7e-09	23128233	CD	.
169	11	128380974	rs11221332	2.44e-09	26974007	IBD	ETS1

图文展示

ID	Chr	Position (bp)	SNP	P value	Study (PMID)	Phenotype	Genes in locus
170	12	6491125	rs7954567	1.3e-09	26192919	CD	LTBR
171	12	12657513	rs11612508	1e-08	23128233	UC	DUSP16,LOH12CR1
172	12	40740223	rs148319899	5.54e-29	FM	IBD	SLC2A13,LRRK2,MUC19
173	12	48208368	rs11168249	8e-09	23128233	UC	HDAC7
174	12	68508122	rs11614178	2.22e-32	FM	IBD	.
175	12	112007756	rs653178	1.11e-08	26192919	IBD	SH2B3,BRAP,ACAD10,ALDH2,TMEM116,NAA25,ATXN2,MAPKAPK5,ERP29,RP11-162P23.2
176	12	120146925	rs11064881	5.95e-08	26192919	IBD	RP1-127H14.3,PRKAB1,CIT
177	13	27531267	rs17085007	3e-19	23128233	UC	.
178	13	41013977	rs941823	2e-14	23128233	IBD	.
179	13	41558110	rs7329174	8e-09	23266558	CD	KBTBD6,KBTBD7,WBP4,ELF1
180	13	42917861	rs80244186	3.66e-08	NOVEL	CD	AKAP11
181	13	43052880	rs2062305	5e-10	21102463	CD	.
182	13	44457925	rs3764147	2e-21	23128233	IBD	LACC1,CCDC122
183	13	49595331	rs2026029	9.73e-09	26974007	CD	MLNR,FNDC3A
184	13	99956622	rs9557195	2e-14	23128233	IBD	GPR18,GPR183,UBAC2
185	14	69210199	rs4902642	2e-10	21102463	IBD	ZFP36L1
186	14	75741751	rs1569328	3.21e-09	26192919	IBD	FOS,RP11-293M10.1
187	14	88472595	rs8005161	4e-18	21102463	IBD	GALC,GPR65
188	15	38899190	rs16967103	4e-09	23128233	IBD	RASGRP1
189	15	41563950	rs28374715	2e-08	23128233	UC	EXD1,OIP5,NUSAP1,RTF1,INO80,CHP1,NDUFAF1
190	15	67442596	rs17293632	2.71e-20	26192919	IBD	SMAD3
191	15	91172901	rs7495132	9e-11	23128233	IBD	CRTC3
192	16	11373320	rs529866	2e-16	23128233	CD	SOCS1,TNP2,PRM3,PRM2,PRM1,RMI2,LITAF,CTD-3088G3.8
193	16	23864590	rs7404095	1e-09	23128233	IBD	PRKCB
194	16	28528781	rs28449958	7.5e-24	FM	IBD	IL27,NUPR1,TUFM,NPIPB6,EIF3CL,NPIPB7,CLN3,CLN3,APOBR,SULT1A2,SULT1A1,NPIPB8,NPIPB9,SH2B1,ATP2A1,RABEP2,CD19,CCDC101,EIF3C,ATXN2L
195	16	30482494	rs11150589	1.63e-11	FM	UC	ITGAL
196	16	50335074	rs78534766	1.17e-14	NOVEL* (Luo et al, In Press)	UC	ADCY7
197	16	50745926	rs2066844	2.27e-217	FM	IBD	SNX20,NOD2,CYLD,NKD1
198	16	68591230	rs1728785	3e-08	19915572	UC	ZFP90,CDH3
199	16	81916912	rs11548656	5.18e-11	NOVEL	IBD	PLCG2
200	16	82867456	rs10492862	1.26e-09	NOVEL	CD	CDH13
201	16	86014241	rs16940202	6e-19	21297633	IBD	.
202	17	25869033	rs10775412	2.51e-25	FM	CD	KSR1
203	17	32593974	rs3091316	1e-26	23128233	IBD	AC005549.3,CCL2,CCL7,CCL11
204	17	37912377	rs12946510	2.16e-39	26192919	IBD	GSDMB,ORMDL3,LRRC3C,GRB7,ZPBP2,GSDMA,IKZF3
205	17	40527544	rs12942547	6e-22	23128233	IBD	NAGLU,STAT5A,PTRF,STAT5B,STAT3,ATP6V0A1
206	17	54880993	rs3853824	7.7e-10	26192919	IBD	C17orf67,DGKE
207	17	57963537	rs1292053	9e-13	23128233	IBD	TUBD1,RPS6KB1,RP11-178C3.1,RNFT1,VMP1
208	17	70642923	rs17780256	3.19e-11	26192919	IBD	SLC39A11
209	17	76737118	rs17736589	4.34e-08	26192919	UC	CYTH1,USP36
210	18	12818922	rs80262450	3.97e-28	FM	IBD	PTPN2
211	18	46395022	rs7240004	1.01e-10	26192919	IBD	.
212	18	56879827	rs9319943	9.05e-07	26192919	CD	.
213	18	67530439	rs727088	5e-09	23128233	IBD	CD226,DOK6
214	18	77220616	rs7236492	1.45e-08	26192919	IBD	NFATC1
215	19	1124031	rs2024092	8e-22	23128233	IBD	GPX4,SBNO2,STK11
216	19	10512911	rs11879191	5.27e-20	26192919	IBD	CTD-2369P2.12,ICAM3,ZGLP1,CTD-2369P2.10,FDX1L,RAVER1,CDC37,PDE4A,KEAP1,TYK2
217	19	33731551	rs17694108	6e-15	23128233	IBD	.
218	19	34656406	rs587259	2.98e-08	26974007	CD	LSM14A
219	19	46849806	rs4802307	9.04e-12	26192919	CD,UC	CCDC8,PNMAL2,AC011484.1,CALM3,PTGIR,GNG8,PPP5C,PNMAL1,PPP5D1,AC011551.3
220	19	49206172	rs516246	1.33e-20	26192919	CD	IZUMO1,NTN5,FUT2,MAMSTR,RASIP1
221	19	55383051	rs11672983	7e-11	23128233	IBD	KIR3DL2,FCAR,KIR3DL1
222	20	6093889	rs4256018	1.23e-08	NOVEL	IBD	FERMT1
223	20	30725648	rs6142618	6e-10	23128233	IBD	TM9SF4,PLAGL2,KIF3B,ASXL1,POFUT1,C20orf112
224	20	31376282	rs4911259	1e-09	23128233	IBD	DNMT3B,MAPRE1,COMMD7,EFCAB8
225	20	33799280	rs6088765	2e-08	23128233	IBD	EIF6,FAM83C,EDEM2,MMP24
226	20	43065028	rs6017342	5.17e-50	FM	UC	C20orf62,SERINC3,PKIG,Z97053.1,TTPAL,ADA
227	20	44742064	rs1569723	1e-13	23128233	IBD	CD40,SLC12A5,NCOA5
228	20	48955424	rs913678	5.35e-11	26192919	IBD	.
229	20	57824309	rs259964	1e-12	23128233	IBD	ZNF831
230	20	62329099	rs6062496	6.76e-26	FM	IBD	TNFRSF6B,ARFRP1,LIME1,RP4-583P15.14,STMN3,RTEL1,RTEL1-TNFRSF6B,ZGPAT,RP4-583P15.15,SLC2A4RG,ZBTB46
231	21	16817938	rs2823286	9e-30	23128233	IBD	.
232	21	34776695	rs2284553	5.63e-17	26192919	CD	IFNGR2
233	21	40465534	rs2836878	5e-48	23128233	IBD	.
234	21	45615741	rs7282490	9.85e-30	26192919	IBD	.
235	22	21922904	rs2266959	1e-16	23128233	IBD	YDJC,SDF2L1,UBE2L3,CCDC116
236	22	30493882	rs5763767	8.82e-15	26192919	IBD	UQCR10,ASCC2,ZMAT5,HORMAD2,MTMR3
237	22	35729721	rs138788	2.95e-08	NOVEL	UC	TOM1
238	22	37258503	rs4821544	1.76e-08	NOVEL	CD	NCF4
239	22	39659773	rs2413583	5.06e-38	26192919	IBD	SYNGR1,RPL3
240	22	41867377	rs727563	1.88e-10	26192919	CD	DNAJB7,AL035681.1,TOB2,ST13,RBX1,L3MBTL2,CHADL,ZC3H7B,TEF,PHF5A,ACO2,POLR3H,CSDC2,PMM1,DESI1,XRCC6,C22orf46,MEI1,XPNPEP3,EP300,RANGAP1,NHP2L1,CCDC134
241	22	50435480	rs5771069	4e-08	20228798	UC	PIM3,IL17REL,TTLL8

Ref:de Lange KM, Moutsianas L, Lee JC, et al. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. Nat Genet. 2017 Feb;49(2):256-261. doi: 10.1038/ng.3760 Epub 2017 Jan 9. PMID: 28067908 PMCID: PMC5289481

IBD associated SNPs

‍

Chr	Position (hg19 (Mb))	SNP	Key Genes	p-value	OR
Crohn's Disease
1	78.62	rs17391694	(5)	2.96E-09	1.134
1	114.3	rs6679677§	PTPN22,DCLRE1B,(7)	2.03E-15	1.196^
1	120.45	rs3897478	ADAM30,(5)	1.97E-11	1.161
1	172.85	rs9286879	FASLG,TNFSF18,(0)	5.53E-22	1.125
2	27.63	rs1728918	UCN,(23)	4.86E-16	1.123
2	62.55	rs10865331	(3)	9.77E-10	1.098
2	231.09	rs6716753	SP140,(5)	1.17E-16	1.134
2	234.145	rs12994997	ATG16L1, INPP5D, (7)	4.14E-70	1.233
4	48.36	rs6837335	TXK,TEC,SLC10A4,(3)	1.75E-08	1.086
4	102.86	rs13126505	(1)	1.84E-12	1.172
5	55.43	rs10065637	IL6ST,IL31RA,(1)	3.68E-12	1.123
5	72.54	rs7702331	(4)	5.63E-10	1.088
5	173.34	rs17695092	CPEB4,(2)	4.68E-09	1.095
6	21.42	rs12663356	(3)	4.01E-12	1.095
6	31.27	rs9264942	HLA-C,PSORS1C1,NFKBIL1,MICB,(18)	4.96E-28	1.145
6	127.45	rs9491697	(3)	3.79E-10	1.077
6	128.24	rs13204742	(2)	8.38E-15	1.173
6	159.49	rs212388	TAGAP,(5)	3.04E-14	1.105
7	26.88‡	rs10486483	(2)	3.48E-08	1.089
7	28.17	rs864745	CREB5,JAZF1,(1)	3.65E-09	1.087
8	90.87	rs7015630	RIPK2,(4)	1.42E-08	1.075
8	129.56	rs6651252	(0)	1.45E-16	1.185
13	44.45	rs3764147	LACC1,(3)	2.19E-21	1.155
15	38.89	rs16967103	RASGRP1,SPRED1,(2)	3.88E-09	1.088
16	50.66**	rs2066847§	NOD2,ADCY7,(5)	5.86E-209	3.103^
17	25.84	rs2945412	LGALS9,NOS2,(3)	8.68E-17	1.137
19	1.12	rs2024092	GPX4,HMHA1,(20)	8.26E-22	1.156
19	46.85‡	rs4802307	(9)	2.00E-10	1.099
19	49.2	rs516246	DBP,SPHK2,IZUMO1,FUT2,(22)	1.00E-15	1.107
21	34.77	rs2284553	IFNGR2,IFNAR1,IFNAR2,IL10RB,GART,TMEM50B,(6)	2.14E-16	1.123
Ulcerative Colitis
1	2.5	rs10797432	TNFRSF14,MMEL1,PLCH2,(8)	2.62E-12	1.078
1	20.15**	rs6426833	(9)	2.39E-68	1.265
1	200.09	rs2816958	(3)	1.98E-17	1.23
2	198.65	rs1016883	RFTN2,PLCL1,(7)	2.87E-08	1.1
2	199.70*	rs17229285	(0)	1.73E-13	1.117
3	53.05	rs9847710	PRKCD,ITIH4,(8)	1.05E-08	1.064
4	103.51	rs3774959	NFKB1,MANBA,(2)	3.66E-12	1.118
5	0.59	rs11739663	SLC9A3,(8)	1.81E-08	1.071
5	134.44	rs254560	(6)	2.55E-09	1.056
6	32.595	rs6927022	HLA-DQB1,HLA-DRB1,HLA-DQA1,HLA-DRA,(12)	4.71E-133	1.444
7	2.78	rs798502	CARD11,GNA12,TTYH3,(4)	6.09E-17	1.127
7	27.22‡	rs4722672	(14)	2.06E-08	1.091
7	107.45*	rs4380874	DLD,(9)	2.07E-26	1.137
7	128.57	rs4728142	IRF5,TNPO3,TSPAN33,(11)	4.37E-14	1.104
11	96.02	rs483905	JRKL,MAML2,(2)	1.21E-08	1.056
11	114.38	rs561722	FAM55A,FAM55D,(5)	5.15E-17	1.12
15	41.55	rs28374715	ITPKA,NDUFAF1,NUSAP1,(8)	2.43E-08	1.082
16	30.47	rs11150589	ITGAL,(20)	6.04E-10	1.09
16	68.58	rs1728785	ZFP90,(6)	3.71E-08	1.075
17	70.64	rs7210086	(3)	1.89E-09	1.111
19	47.12‡	rs1126510	CALM3,(14)	1.55E-09	1.075
20	33.8	rs6088765	PROCR,UQCC,CEP250,(8)	2.21E-08	1.079
20	43.06	rs6017342	ADA,HNF4A,(9)	1.43E-43	1.228
Inflammatory Bowel Disease
1	1.24	rs12103	TNFRSF18,TNFRSF4,(30)	7.66E-13	1.099
1	8.02	rs35675666	TNFRSF9,(6)	1.12E-15	1.112
1	22.7	rs12568930†	(3)	1.26E-17	1.095
1	67.68**	rs11209026†	IL23R,IL12RB2,(4)	8.12E-161	2.013
1	70.99	rs2651244†	(3)	2.29E-08	1.015
1	151.79	rs4845604†	RORC,(14)	3.52E-16	1.144
1	155.67	rs670523†	UBQLN4,RIT1,MSTO1,(28)	5.79E-11	1.06
1	160.85	rs4656958†	CD48,SLAMF1,ITLN1,CD244,F11R,USF1,SLAMF7,ARHGAP30,(8)	6.80E-09	1.061
1	161.47	rs1801274†	FCGR2A,FCGR2B,FCGR3A,HSPA6,FCGR3B,FCRLA,(9)	2.12E-38	1.124
1	197.6	rs2488389	C1orf53,(2)	8.45E-13	1.115
1	200.87	rs7554511	KIF21B,(6)	1.24E-32	1.164
1	206.93	rs3024505†	IL10,IL20,IL19,IL24,PIGR,MAPKAPK2,FAIM3,RASSF5,(3)	6.66E-42	1.208
2	25.12	rs6545800†	ADCY3,(6)	6.14E-16	1.109
2	28.61	rs925255†	FOSL2,BRE,(1)	2.67E-15	1.092
2	43.81	rs10495903†	(5)	8.03E-12	1.086
2	61.2	rs7608910	REL,C2orf74,KIAA1841,AHSA2,(6)	8.65E-32	1.138
2	65.67	rs6740462	SPRED2,(1)	2.35E-08	1.081
2	102.86*	rs917997†	IL1R2,IL18RAP,IL18R1,IL1R1,IL1RL1,IL1RL2,(3)	3.12E-20	1.103
2	163.1	rs2111485	IFIH1,(5)	1.93E-08	1.066
2	191.92	rs1517352	STAT1,STAT4,(2)	3.28E-11	1.077
2	219.14	rs2382817	SLC11A1,CXCR2,CXCR1,PNKD,ARPC2,TMBIM1,CTDSP1,(8)	3.70E-12	1.073
2	241.57*	rs3749171†	GPR35,(12)	3.07E-21	1.135
3	18.76	rs4256159†	(0)	9.00E-15	1.107
3	48.96**	rs3197999	MST1,PFKFB4,MST1R,UCN2,GPX1,IP6K2,BSN,IP6K1,USP4,(56)	1.01E-47	1.18
4	74.85	rs2472649†	CXCL5,CXCL1,CXCL3,IL8,CXCL6,PF4,CXCL2,PF4V1,(3)	2.57E-08	1.095
4	123.22	rs7657746	IL2,IL21,(2)	2.76E-13	1.116
5	10.69	rs2930047	DAP,(2)	1.03E-08	1.065
5	40.38**	rs11742570†	PTGER4,(1)	1.81E-82	1.198
5	96.24	rs1363907	ERAP2,ERAP1,LNPEP,(2)	5.62E-13	1.068
5	130.005	rs4836519†	(1)	4.24E-10	1.072
5	131.19*	rs2188962†	IRF1,IL13,CSF2,SLC22A4,IL4,IL3,IL5,PDLIM4,SLC22A5,ACSL6,(8)	1.35E-52	1.158
5	141.51	rs6863411†	SPRY4,NDFIP1,(5)	3.59E-14	1.089
5	150.27	rs11741861†	TNIP1,IRGM,ZNF300P1,(8)	2.94E-37	1.249
5	158.8**	rs6871626†	IL12B,(3)	1.43E-42	1.181
5	176.79	rs12654812	DOK3,(17)	1.68E-08	1.068
6	14.71	rs17119	(0)	3.08E-11	1.071
6	20.77*	rs9358372†	(2)	8.66E-14	1.089
6	90.96	rs1847472	(1)	1.57E-10	1.06
6	106.43	rs6568421†	(2)	8.24E-20	1.108
6	111.82	rs3851228	TRAF3IP2,FYN,REV3L,(2)	1.08E-13	1.153
6	138	rs6920220†	TNFAIP3,(1)	1.40E-21	1.102
6	143.9	rs12199775	PHACTR2,(5)	1.99E-08	1.129
6	167.37	rs1819333†	CCR6,RPS6KA2,RNASET2,(3)	6.76E-21	1.081
7	50.245*	rs1456896	ZPBP,IKZF1,(4)	7.28E-15	1.088
7	98.75	rs9297145	SMURF1,(6)	8.21E-12	1.082
7	100.335	rs1734907†	EPO,(21)	1.67E-13	1.114
7	116.89	rs38904†	(6)	1.31E-08	1.054
8	126.53	rs921720†	TRIB1,(1)	8.30E-20	1.081
8	130.62	rs1991866	(2)	1.65E-09	1.054
9	4.98	rs10758669	JAK2,(4)	7.88E-45	1.174
9	93.92	rs4743820†	NFIL3,(2)	3.60E-09	1.056
9	117.60**	rs4246905	TNFSF8,TNFSF15,TNC,(2)	2.80E-32	1.142
9	139.32*	rs10781499†	CARD9,PMPCA,SDCCAG3,INPP5E,(19)	4.38E-56	1.188
10	6.08	rs12722515†	IL2RA,IL15RA,(6)	3.76E-10	1.102
10	30.72	rs1042058†	MAP3K8,(3)	5.93E-11	1.075
10	35.295	rs11010067†	CREM,(3)	2.49E-25	1.115
10	59.99	rs2790216	CISD1,IPMK,(2)	8.07E-09	1.066
10	64.51**	rs10761659†	(3)	6.37E-46	1.166
10	75.67	rs2227564†	(13)	6.75E-10	1.082
10	81.03	rs1250546†	(5)	3.15E-18	1.096
10	82.25	rs6586030†	TSPAN14,C10orf58,(4)	9.24E-16	1.115
10	94.43	rs7911264	(4)	2.98E-08	1.066
10	101.28	rs4409764	NKX2-3,(6)	1.03E-54	1.182
11	1.87	rs907611	TNNI2,LSP1,(17)	2.70E-10	1.068
11	58.33	rs10896794	CNTF,LPXN,(8)	6.80E-10	1.08
11	60.77	rs11230563	CD6,CD5,PTGDR2,(12)	9.03E-13	1.085
11	61.56	rs4246215†	C11orf9,FADS1,FADS2,(12)	1.93E-15	1.079
11	64.12	rs559928	CCDC88B,RPS6KA4,TRPT1,FLRT1,(20)	4.19E-11	1.101
11	65.65	rs2231884†	RELA,FOSL1,CTSW,SNX32,(22)	2.91E-10	1.083
11	76.29	rs2155219†	(5)	4.24E-36	1.151
11	87.12	rs6592362	(1)	2.32E-08	1.083
11	118.74	rs630923†	CXCR5,(17)	7.07E-09	1.074
12	12.65	rs11612508†	LOH12CR1,(8)	1.06E-08	1.058
12	40.77*	rs11564258†	LRRK2,MUC19	6.38E-29	1.334
12	48.2	rs11168249†	VDR,(8)	7.78E-09	1.054
12	68.49	rs7134599†	IFNG,IL26,IL22,(1)	8.51E-32	1.096
13	27.52	rs17085007†	(2)	2.79E-19	1.106
13	40.86**	rs941823†	(3)	2.07E-14	1.071
13	99.95	rs9557195	GPR183,GPR18,(6)	2.37E-14	1.112
14	69.27	rs194749†	ZFP36L1,(4)	2.70E-10	1.075
14	75.7	rs4899554†	FOS,MLH3,(6)	2.71E-08	1.083
14	88.47	rs8005161	GPR65,GALC,(1)	2.35E-14	1.153
15	67.43	rs17293632†	SMAD3,(2)	5.97E-16	1.067
15	91.17	rs7495132	CRTC3,(3)	9.48E-11	1.134
16	11.54*	rs529866†	SOCS1,LITAF,RMI2,(10)	1.73E-16	1.124
16	23.86	rs7404095	PRKCB,(5)	9.68E-10	1.06
16	28.595	rs26528†	RABEP2,IL27,EIF3C,SULT1A1,SULT1A2,NUPR1,(9)	9.65E-22	1.099
16	86	rs10521318†	IRF8,(4)	1.41E-09	1.155
17	32.59	rs3091316†	CCL13,CCL2,CCL11,(4)	1.22E-26	1.122
17	37.91	rs12946510	IKZF3,ZPBP2,GSDMB,ORMDL3,GSDMA,(12)	4.10E-38	1.157
17	40.53	rs12942547†	STAT3,STAT5B,STAT5A,(13)	5.51E-22	1.103
17	57.96	rs1292053†	TUBD1,RPS6KB1,(9)	8.85E-13	1.076
18	12.8	rs1893217†	(6)	3.05E-26	1.171
18	46.39	rs7240004†	SMAD7,(2)	1.31E-09	1.057
18	67.53	rs727088	CD226,(2)	4.65E-09	1.077
19	10.49*	rs11879191	TYK2,PPAN-P2RY11,ICAM1,(25)	2.04E-18	1.136
19	33.73	rs17694108	CEBPG,(8)	5.85E-15	1.1
19	55.38	rs11672983	NLRP7,NLRP2,KIR2DL1,LILRB4,(15)	6.50E-11	1.087
20	30.75	rs6142618†	HCK,(10)	6.05E-10	1.072
20	31.37	rs4911259	DNMT3B,(8)	1.20E-09	1.075
20	44.74	rs1569723†	CD40,MMP9,PLTP,(11)	9.95E-14	1.091
20	48.95	rs913678	CEBPB,(5)	4.59E-08	1.056
20	57.82	rs259964	ZNF831,CTSZ,(5)	1.01E-12	1.085
20	62.34	rs6062504	TNFRSF6B,LIME1,SLC2A4RG,ZGPAT,(23)	1.09E-23	1.104
21	16.81	rs2823286†	(0)	9.28E-30	1.157
21	40.46	rs2836878†	(3)	4.62E-48	1.18
21	45.62	rs7282490	ICOSLG,(9)	2.35E-26	1.105
22	21.92	rs2266959	MAPK1,YDJC,UBE2L3,RIMBP3,CCDC116,(8)	1.39E-16	1.105
22	30.425	rs2412970	LIF,OSM,MTMR3,(8)	2.70E-14	1.08
22	39.69*	rs2413583†	ATF4,TAB1,APOBEC3G,(16)	4.40E-33	1.209

The position given is the middle of thelocus window

* = additional genome-wide significantassociated SNP in the region

** = two or more additional genome-widesignificant SNPs in the region

‡ = These regions have overlapping butdistinct UC and CD signals

Bolded rs numbers indicate SNPs withp-values less than 10-13

† = heterogeneity of odds ratios

§ = CD risk allele is significantlyprotective in UC

Listed are genes implicated by one or morecandidate genes approaches. Bolded genes have been implicated by two or morecandidate gene approaches. For each locus, the top two candidate genes arelisted. A complete listing of gene prioritization is provided in SupplementaryTable 2

‖gene for which functional studies of associated alleles have been reported

Newly discovered loci

Ref: Jostins L, Ripke S, Weersma RK, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature. 2012 Nov 1;491(7422):119-24. doi: 10.1038/nature11582. PMID: 23128233.

图文展示

Chr.	BP position	SNP	Candidate Genes	P-Value	OR
b. Crohn's Disease
1	63049593	rs1748195	USP1	7.13×10-8	1.07 (1.04-1.1)
1	186875459	rs10798 069	PTGS2,PLA2G 4A	4.25×10-9	0.93 (0.91-0.95)
1	198598663	rs7555082	PTPRC	1.47×10-10	1.13 (1.09-1.17)
2	145492382	rs11681 525	-	4.08×10-11	0.86 (0.82-0.90)
2	242737341	rs35320 439	PDCD1,ATG4B	9.89×10-10	1.09 (1.06-1.12)
3	141105570	rs724016	-	3.36×10-6	1.06 (1.04-1.09)
6	382559	rs7773324	IRF4,DUSP22	1.06×10-9	0.92 (0.90-0.94)
6	3420406	rs13204048	-	2.89×10-8	0.93 (0.91-0.95)
6	149577079	rs7758080	MAP3K7IP2	7.27×10-9	1.08 (1.05-1.11)
12	6491125	rs7954567	CD27,TNFRSF 1A,LTBR	1.30×10-9	1.09 (1.06-1.12)
13	43018030	rs9525625	AKAP1, TFSF11	1.41×10-9	1.08 (1.05-1.11)
17	54880993	rs3853824	-	1.17×10-10	0.92 (0.90-0.94)
18	56879827	rs9319943	-	9.05×10-7	1.08 (1.05-1.11)
18	77220616	rs7236492	NFATC1, TST	9.09×10-9	0.91 (0.88-0.94)
22	41867377	rs727563	TEF, NHP2L1, PMM1, L3MBTL2, CHAD	1.88×10-10	1.1 (1.07-1.13)
b. Ulcerative Colitis
1	101466054	rs11583043	SLC30A, EDG1	6.05×10-8	1.08 (1.05-1.11)
2	204592021	rs31164 94	ICOS,CD28,CT LA4	1.30×10-7	1.08 (1.05-1.11)
3	46457412	rs11301 0081	FLJ78302,LTF, CCR1,CCR2, CCR3,CCR5	9.02×10-10	1.14 (1.09-1.19)
3	101569726	rs616597	NFKBIZ	9.34×10-6	0.93 (0.90-0.96)
4	106075498	rs2189234	-	1.95×10-10	1.08 (1.05-1.11)
7	17442679	rs1077773	AHR	5.96×10-9	0.93 (0.91-0.95)
8	49129242	rs7011507	-	6.40×10-8	0.9 (0.87-0.93)
17	76737118	rs17736589	-	4.34×10-8	1.09 (1.06-1.12)
b. Inflammatory Bowel Diseases
1	92554283	rs34856868	BTBD8	9.80×10-9	0.82 (0.77-0.88)
1	169519049	rs6025	SELP,SELE,SE LL	2.51×10-8	0.84 (0.79-0.89)
2	160794008	rs4664304	MARCH7,LY75,PLA2R1	2.61×10-8	1.06 (1.04-1.08)
2	228660112	rs11178 1203	CCL20	2.16×10-10	0.94 (0.92-0.96)
4	3444503	rs2073505	HGFAC	1.46×10-7	1.1 (1.06-1.14)
4	26132361	rs4692386	-	1.21×10-8	0.94 (0.92-0.96)
4	38325036	rs6856616	-	9.72×10-7	1.1 (1.06-1.14)
5	38867732	rs395157	OSMR,FYB, LIFR	2.22×10-20	1.1 (1.08-1.12)
5	71693899	rs4703855	-	7.16×10-11	0.93 (0.91-0.95)
5	172324978	rs564349	C5orf4, DUSP1	1.54×10-7	1.06 (1.04-1.08)
7	148220448	rs2538470	CNTNAP2	3.00×10-11	1.07 (1.05-1.09)
8	27227554	rs17057051	PTK2B,TRIM 35,EPHX2,	5.50×10-8	0.94 (0.92-0.96)
10	104232716	rs3740415	NFKB2, TRIM8, TMEM180	1.03×10-7	0.95 (0.93-0.97)
12	112007756	rs653178	SH2B3, ALDH2,ATXN 2	1.11×10-8	1.06 (1.04-1.08)
12	120146925	rs11064881	PRKAB1	5.95×10-8	1.1 (1.06-1.14)

b.Phenotype with the largest MANTRA Bayes factor

Ref: Liu JZ, van Sommeren S, Huang H,et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet. 2015 Sep;47(9):979-986. doi: 10.1038/ng.3359.Epub 2015 Jul 20. PMID: 26192919.

Genome-wide association and Immunochip studies on inflammatory bowel disease susceptibility genes in Asia .

Chr	Position	SNP	Positional Candidate Gene or Region	Replicated Gene or Region	PMID
Crohn's Disease
4 13	38334202 40983974	rs1487630 rs7329174	4p14 ELF1	MHC TNFSF15 STAT3	23266558
4 10 11 11	38323415 110426390 72822491 73152652	rs6856616 rs11195128 rs11235604 rs11235667	TBC1D1-KLF3 SMNDC1-DUSP5 ATG16L2 ATG16L2-FCHSD2	TNFSF15 IL23R MHC RNASET2-FGFR10P-CCR6	23850713

1	111720204	rs488200	RAP1A	TNFSF15	30500874
				HLA-DQB1
				4p14
				ZNF365
				IL12B
				IL27
Ulcerative colitis				IL23R G149R
1	161509955	rs1801274	FCGR2A	JAK2, INSL6, INSL4	19915573
13	26957130	rs17085007	13q12	MHC
7	107812658	rs2108225	SLC26A3
6	31635814	rs2261033	BAT2	PTPRC	23511034
6	31876147	rs2736428	SLC44A4	MHC
6	31810169	rs2075800	HSPA1L	TAP2
6	32237268	rs549182	NOTCH4
6	31949763	rs4151657	CFB
6	31481085	rs3749946	3.8-1/HCG26
6	31758911	rs707939	MSH5

CD = Crohn’s disease, UC = ulcerative colitis, GWAS = genome-wide association study, MHC = major histocompatibility complex, () = denotes nearby genes.

Ref: Park SC, Jeen YT. Genetic Studies of Inflammatory Bowel Disease Focusing on Asian Patients. Cells. 2019 May 1; 8(5):404. doi: 10.3390/cells8050404

IBD risk SNPs File Download

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