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The IBD Metabolism

ID
Study
Disease
Study context
Omics type
Volunteers
Nation

Control/   

non-IBD ?

PMID
1
Lloyd-Price et al., 2019
CD, UC
Identification of multi-omic signatures associated with IBD patients

Faecal

metabolomics

132
USA
Yes
31142855
2
Borren et al., 2020
CD, UC
Prediction of biomarkers associated with disease relapse

Faecal   

metabolomics

164
USA
No
32766830
3
Suskind et al., 2020
CD
Investigating the effect of different diets on disease symptoms and inflammatory burden

Faecal   

metabolomics

18
USA
No
33291229
4
Nusbaum et al., 2018
UC
Influence of FMT on gut microbial and metabolic activity in paediatric UC patients

Faecal   

metabolomics

7
USA
No
30010747
5
Metwaly et al., 2020
CD
Integrative analysis of metabolic and microbial profiles in CD

Faecal   

metabolomics

29
Germany
No
32859898
6
Franzosa et al., 2019
CD, UC
Investigation of microbiome and metabolic activity in IBD

Faecal   

metabolomics

220
USA
Yes
30531976
7
Lee JWJ et al., 2021
CD, UC
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease

Blood   

metabolomics

185
USA
No
34297922
8
Xiaomin Yuan et al., 2022
UC
Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics

Blood   

metabolomics

240
China
Yes
34806521
9
Mills RH et al., 2022
UC
To understand how host-microbiota interactions become disrupted in UC

Faecal   

metabolomics

250
USA
Yes
35087228
10
Frau A et al., 2022
CD, UC
Inter-kingdom relationships in Crohn's disease explored using a multi-omics approach

Faecal   

metabolomics

104
UK
Yes
34241567
11
Bushman FD et al., 2022
CD, UC
Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease

Faecal   

metabolomics

97
USA
Yes
32822584
12
Taylor H et al., 2022
CD
To identify changes in the microbiota, metabolome and protease activity associated with mucosal healing in established paediatric CD

Faecal   

metabolomics

25
UK
No
32929796
13
Ghiboub M et al., 2022
CD
Metabolome Changes With Diet-Induced Remission in Pediatric Crohn's Disease

Faecal   

metabolomics

74
Netherlands
No
35679949
14   Weng YJ et        al.,2019CD, UC   Correlation of diet, microbiota and metabolite networks in inflammatory      bowel disease

   Faecal   

   metabolomics

113

ChinaYes

31240835

15   Hu J et al., 2022CD Correlation between altered gut microbiota and elevated inflammation       markers in patients with Crohn's disease   Faecal short-   chain fatty acids

182

ChinaYes36045690
16   Cheng S et al., 2021CD, UC Altered gut microbiome in FUT2 loss-of-function mutants in support of   personalized medicine for inflammatory bowel diseases   Faecal short-chain fatty acids

81

ChinaNo34419617
17   Wang Y et al., 2021CD Microbial and metabolic features associated with outcome of infliximab   therapy in pediatric Crohn's disease

   Faecal   

   metabolomics

49

ChinaYes33430702
18   Liu H et al., 2022CD Untargeted serum metabolomics reveals specific metabolite abnormalities   in patients with Crohn's disease

   Blood

   metabolomics

266

ChinaYes36160171
19   Tian Z et al., 2022CD Dietary inflammatory potential mediated gut microbiota and metabolite   alterations in Crohn's disease: A fire-new perspective

   Faecal and          Blood

metabolomics

130

ChinaYes35504169
20   Ijaz UZ et al., 2022CD The distinct features of microbial 'dysbiosis' of Crohn's disease do not   occur to the same extent in their unaffected, genetically-linked kindred   Faecal short-chain fatty acids50UKYes

28222161

21   Gonzalez CG, et al.,2022CD, UC   Location-specific signatures of Crohn's disease at a multi-omics scale

   Faecal

   metabolomics

182USAYes35999575
22   Cox SR et al., 2020CD Effects of Low FODMAP Diet on Symptoms, Fecal Microbiome, and   Markers of Inflammation in Patients With Quiescent Inflammatory Bowel   Disease in a Randomized Trial   Faecal short-   chain fatty acids52UKNo31586453
23   Borren NZ et al., 2021CD, UC Alterations in Fecal Microbiomes and Serum Metabolomes of Fatigued   Patients With Quiescent Inflammatory Bowel Diseases

   Blood

   metabolomics

166USANo32184182
24   Verburgt CM et al., 2022CD
Successful Dietary Therapy in Paediatric Crohn's Disease is Associated   with Shifts in Bacterial Dysbiosis and Inflammatory Metabotype Towards   Healthy Controls   Faecal Short chain fatty acids and bile acids80NetherlandsYes36106847




IBDMDB metabolomics data
iHMP_IBD_metabolomics.xlsx
193.06MB下载14次下载
iHMP_IBD_Sample data.csv
8.65MB下载14次下载
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